Choline theophyllinate


Generic Medicine Info
Indications and Dosage
Oral
Reversible airways obstruction
Adult: Initially, 0.2-0.4 g daily and increase gradually according to response. Maintenance: 0.8-1.2 g daily in 3-4 divided doses.
Child: 10-14 yrs: 400-800 mg in 4 divided doses; 5-9 yrs: 200-400 mg in 4 divided doses; <5 yrs: 24-36 mg/kg body weight/day in 3 divided doses.
Special Precautions
Peptic ulceration, hyperthyroidism, hypertension, cardiac arrhythmias or other CV diseases, epilepsy, hepatic dysfunction, chronic alcoholism, acute febrile illness; smoking; neonates; elderly; pregnancy, lactation.
Adverse Reactions
GI irritation and disturbances, CNS stimulation, headache, anxiety, restlessness, dizziness, tremor, palpitations.
Drug Interactions
Xanthines (additive effects), allopurinol, some antiarrhythmics, cimetidine, disulfiram, fluvoxamine, interferon-α, macrolide antibacterials, quinolones, oral contraceptives, tiabendazole, viloxazine, anticonvulsants, ritonavir, rifampicin, sulfinpyrazone, halothane, ketamine, β-blockers.
Action
Description:
Mechanism of Action: Choline theophyllinate is a theophylline salt which liberates theophylline in the body. It inhibits the activity of phosphodiesterase, resulting in the intracellular accumulation of cyclic adenosine monophosphate (cAMP), thus leading to bronchodilation.
MIMS Class
Antiasthmatic & COPD Preparations
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